Anti-Aging Mechanisms of NAD+

By Stephen Harrington Scientists are discovering new ways that NAD+ facilitates healthy longevity.1-3 NAD+ levels markedly decline with age, creating an energy deficit that decreases the body’s ability to retain youthful function.4 To give you an idea how impactful NAD+ can be, by age 50 a typical person may have only half the NAD+ they did in youth. By age 80, NAD+ levels drop to only 1% to 10% expressed in …

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Human Clinical Trials

It is important to note that many pre-clinical studies have been conducted testing NR in various model systems. In 2015, the first human clinical studies were completed and the results demonstrated that NR safely and effectively boosts levels of NAD in healthy human volunteers. In addition to these studies, there are approximately 21 additional human clinical trials …

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What is NAD+ and Why Is it Important for Aging and Health?

What is NAD+ and Why Is it Important for Aging and Health? You can’t live without the coenzyme NAD+, nicotinamide adenine dinucleotide. Here’s why it’s so important, how it was discovered, and how you can get more of it. 07.31.18 NAD+, or nicotinamide adenine dinucleotide, is a coenzyme found in all living cells, and it’s …

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Scientists Can Reverse DNA Aging in Mice

Scientists Can Reverse DNA Aging in Mice http://time.com/4711023/how-to-keep-your-dna-from-aging/ By ALICE PARK March 23, 2017 TIME Health For more, visit TIME Health. Researchers have found a way to protect a mouse’s DNA from the damage that comes with aging, and they’re ready to test it in people. Dr. David Sinclair, from Harvard Medical School, and his colleagues reveal their …

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Nicotinamide adenine dinucleotide – wikipedia

Nicotinamide adenine dinucleotide From Wikipedia, the free encyclopedia Nicotinamide adenine dinucleotide Names Other names Diphosphopyridine nucleotide (DPN+), Coenzyme I Identifiers CAS Number 53-84-9  58-68-4 (NADH)  3D model (JSmol) Interactive image ChEBI CHEBI:16908  ChEMBL ChEMBL1628272  ChemSpider 5681  DrugBank DB00157  ECHA InfoCard 100.000.169 IUPHAR/BPS 2451 KEGG C00003  PubChem CID 925 RTECS number UU3450000 UNII 0U46U6E8UK  InChI[show] SMILES[show] Properties Chemical …

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Anti-Aging Approaches

Anti-Aging Approaches   by MARINA N. BOLOTNIKOVA SEPTEMBER-OCTOBER 2017 Illustration by Hanna Barczyk DECADES of research have shown that calorie restriction extends lifespan and delays morbidity in many small, short-lived species: yeast, spiders, and various fish and rodents. In humans, though, the benefits of calorie restriction are still unproven, and probably less straightforward. And howcalorie restriction slows the …

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Beyond Resveratrol: The Anti-Aging NAD Fad

Beyond Resveratrol: The Anti-Aging NAD Fad Whenever I see my 10-year-old daughter brimming over with so much energy that she jumps up in the middle of supper to run around the table, I think to myself, “those young mitochondria.” Mitochondria are our cells’ energy dynamos. By David Stipp on March 11, 2015 The views expressed are those of …

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NAD+ protects against EAE by regulating CD4+ T-cell differentiation

NAD+ protects against EAE by regulating CD4+ T-cell differentiation Stefan G. Tullius , Hector Rodriguez Cetina Biefer , Suyan Li , Alexander J. Trachtenberg , Karoline Edtinger , Markus Quante , Felix Krenzien , Hirofumi Uehara , Xiaoyong Yang , Haydn T. Kissick , Winston P. Kuo , Ionita Ghiran , Miguel A. de la Fuente , Mohamed S. Arredouani , Virginia Camacho , John C. Tigges , Vasilis Toxavidis , Rachid El Fatim , Brian D. Smith , Anju Vasudevan & Abdallah ElKhal  Nature Communications volume5, Article number: 5101 (2014) | Download Citation Abstract CD4+ T cells are involved in the development …

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